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Pre-op skin prep – Iodine vs chlorhexidine: Which is better?

In this episode, we review two recent randomized control trials investigating this question. “Skin Antisepsis before Surgical Fixation of Extremity Fractures” is a publication from the PREPARE trial in the February 2024 issue of the New England Journal of Medicine. This was a randomized control trial of over 6000 patients in which day investigated iodine versus chlorhexidine for skin prep of both closed and open extremity fracture surgery.

The second paper is in the August 20, 2024 issue of the Journal of the American American Medical Association entitled “Povidone Iodine vs Chlorhexidine Gluconate in Alcohol for Preoperative Skin Antisepsis
A Randomized Clinical Trial”. This was a multi center trial of over 3000 patients at three sites in Switzerland that looked at prevention of SSI and cardiac or abdominal surgery.

Results from both trials are discussed and in this season, we are introducing some surprisingly engaging, artificial intelligence hosts. Enjoy.

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